Butalbital; Acetaminophen; Caffeine; Codeine: Moderate Coadministration of opioid agonists, such as codeine, delay and reduce the absorption of clopidogrel resulting in reduced exposure to active metabolites and diminished inhibition of platelet aggregation.
Concomitant use may increase bupropion exposure but decrease hydroxybupropion exposure.
However, there are potential risks to the mother and fetus if a heart attack or stroke occurs during pregnancy.