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Butalbital; Acetaminophen; Caffeine; Codeine: Moderate Coadministration of opioid agonists, such as codeine, delay and reduce the absorption of clopidogrel resulting in reduced exposure to active metabolites and diminished inhibition of platelet aggregation.

  • Concomitant use may increase bupropion exposure but decrease hydroxybupropion exposure.

  • However, there are potential risks to the mother and fetus if a heart attack or stroke occurs during pregnancy.




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