After Shōta sleeps with the girl, Erika begs for her medication to counteract her drug addiction.
Finally suffering from both drug withdrawal and being chained up in Shota's room, Erica woke up and begged for medicine at night, Shota put the pill in his mouth, and when she was forced to use her mouth to get the pill, Shota used the opportunity to kiss her.
The visible differences aren't much in the face of the absurd situation before Reito's eyes though, with Suou throwing herself at him, Reito sometimes sees Erisa in her and is a step away from letting go of his original love.
In fact, Reito's sister specifically runs a charity to try and mitigate the divide and lessen the suffering as much she can.
At the lunch date, Mahiru rejects Hino, depressing him, but he sleeps with his jealous harem to placate them.
Well, yes, Rito being able to mate was the prime reason behind her creation.